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doi: 10.1007/s12020-019-01982-1 124 CarottiSGuarinoMPLValentiniFPorzioSVespasiani-GentilucciUPerroneGet al

Individual response times vary considerably based on baseline skin tone

Wirkungsmechanismus: Es ahmt die Wirkung von Ghrelin (einem Hungerhormon) nach und bindet an den Ghrelinrezeptor im Gehirn, der dann die Freisetzung von Wachstumshormonen aus der Hypophyse auslst

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However, portal insulin delivery is also an essential co-player in the regulation of the GH/IGF-I axis by affecting and regulating hepatic GH receptor synthesis, and subsequently altering hepatic GH sensitivity and IGF-I generation